Flupyradifurone

SKU: orb1982981

Description

Flupyradifurone is a systemic insecticide that functions as a nicotinic acetylcholine receptor (nAChR) agonist, disrupting insect neurotransmission. It is utilized in agricultural and entomological research, with applications in both in vitro receptor studies and in vivo efficacy experiments against sap-feeding pests.

Research Area

Neuroscience

Key Properties

• CAS Number: 951659-40-8
• MW: 288.68
• Purity: 99.83%
• Formula: C₁₂H₁₁ClF₂N₂O₂
• SMILES: O=C1OCC(=C1)N(CC2=CN=C(Cl)C=C2)CC(F)F
• Target: AChR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.43 mM);DMSO:80 mg/mL (277.12 mM)

Bioactivity

• In Vivo:
  In vivo studies in honey bees (Apis mellifera) show that oral administration of Flupyradifurone (1.2-3.9 µg/bee) causes transient but reversible neurobehavioral symptoms (e.g., tremors and disorientation) without mortality or long-term effects. Flupyradifurone also demonstrates high insecticidal activity against agricultural pests like whiteflies, aphids, and flea beetles, with strong efficacy in field trials.
• In Vitro:
  Flupyradifurone acts as an agonist of nicotinic acetylcholine receptors (nAChRs) in insect nervous systems during in vitro electrophysiological studies. Flupyradifurone causes neuronal depolarization, disrupting nerve signal transmission and resulting in insect death.

Storage & Handling

• Storage: keep away from direct sunlight | store at 4°C | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

16752772