Fluoxetine-Conjugated Platinum(IV) prodrug-1

SKU: orb3027467

Description

Fluoxetine-Conjugated Platinum(IV) prodrug-1 is an eEF2K inhibitor that can hinder the proliferation of cancer cells, induce DNA damage, and cause cell cycle arrest at the S phase, leading to apoptosis (Apoptosis). It also promotes the accumulation of reactive oxygen species (ROS) and disrupts mitochondrial function. This prodrug inhibits the migration and invasion of TNBC cells by suppressing MMP-2 activity and induces autophagy in TNBC cells through AMPK activation. In the 4T1-Luc mouse model, it exhibits antitumor activity and triggers immune suppression. Fluoxetine-Conjugated Platinum(IV) prodrug-1 is relevant for research in triple-negative breast cancer (TNBC).

Research Area

Cell Biology, Epigenetics & Chromatin, Neuroscience, Protein Biochemistry, Signal Transduction

Key Properties

• Formula: C₂₁H₂₈Cl₂F₃N₃O₅Pt
• Target: Autophagy,MMP,AMPK,CaMK,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Autophagy,MMP,AMPK,CaMK,Apoptosis