Fluorizoline

SKU: orb1697186

Description

Fluorizoline is a small molecule that binds prohibitins (PHBs) and exhibits anticancer activity by selectively recruiting the pro-apoptotic BH3 protein NOXA to PHB complexes, triggering apoptosis. It has demonstrated antiproliferative effects and protein synthesis inhibition in leukemia research, with studies conducted both in vitro and in vivo.

Research Area

Cell Biology

Key Properties

• CAS Number: 1362243-70-6
• MW: 362.20
• Purity: 98.22% (May vary between batches)
• Formula: C₁₅H₈Cl₂F₃NS
• SMILES: FC1(F)N=C(SC1(F)c1ccc(Cl)cc1)c1ccc(Cl)cc1
• Target: Apoptosis
• Solubility: DMSO:30 mg/mL (82.83 mM);10% DMSO+90% Corn Oil:2 mg/mL (5.52 mM)

Bioactivity

• In Vitro:
  In primary CLL cells, Fluorizoline (1.25 to 20 μM; 24 hours) significantly reduced cell viability and induced apoptosis in a dose-dependent manner.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Fluorizoline, Apoptosis

Compound Identifiers

PubChem CID

56837157