Fluocinonide

SKU: orb1300712

Description

Fluocinonide is a potent synthetic glucocorticoid used as an anti-inflammatory agent in dermatological research. It is applied in both in vitro and in vivo studies to investigate steroid-mediated pathways and to model inflammatory skin conditions for therapeutic development.

Research Area

Metabolism Research

Key Properties

• CAS Number: 356-12-7
• MW: 494.52
• Purity: >99.99% (May vary between batches)
• Formula: C₂₆H₃₂F₂O₇
• SMILES: [H][C@@]12C[C@@]3([H])[C@]4([H])C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC(C)(C)O2)C(=O)COC(C)=O
• Target: Glucocorticoid Receptor
• Solubility: DMSO:92 mg/mL (186.04 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+90% Corn Oil:3.3 mg/mL (6.67 mM)

Bioactivity

• In Vivo:
  Fluocinonide cream demonstrates lower efficacy for atrophic changes in the skin.
• In Vitro:
  Fluocinonide can effectively induce and maintain pituitary-adrenal cortex suppression in dogs.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Lidex, Metosyn, Glucocorticoid Receptor, GlucocorticoidReceptor, Fluocinonide, Inhibitor, Topsyn

Compound Identifiers

PubChem CID

9642