Fludrocortisone

SKU: orb1307841

Description

Fludrocortisone (Florinef) is a synthetic corticosteroid exhibiting significant mineralocorticoid activity alongside moderate glucocorticoid effects. It is utilized in research settings, particularly for studying hypotension, and serves as a tool in both in vivo and in vitro experiments related to adrenal function and electrolyte balance.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 127-31-1
• MW: 380.45
• Purity: 98.56% (May vary between batches)
• Formula: C₂₁H₂₉FO₅
• SMILES: C[C@]12C[C@H](O)C3(F)[C@@H](CCC4=CC(=O)CC[C@]34C)C1CCC2(O)C(=O)CO
• Target: Glucocorticoid Receptor,Others,Sodium Channel
• Solubility: DMSO:55 mg/mL (144.57 mM)

Bioactivity

• In Vivo:
  METHODS: Wistar rats were treated intravenously with Fludrocortisone （Florinef） (5 and 20 μg/kg). The effects of a single dose of fludrocortisone on systolic blood pressure in normal and endotoxemic rats were evaluated until 2 h after treatment injection and in vitro vasoconstriction to phenylephrine in mesenteric artery rings 3 h after treatment. RESULTS Fludrocortisone increased systolic blood pressure (P < 0.001), but more in endotoxemic than in normal animals. Fludrocortisone significantly improved the contractile response to phenylephrine (P = 0.039 and P = 0.007, respectively).
• In Vitro:
  METHODS: MIO-M1 cells were selected to study the anti-inflammatory effects of Fludrocortisone （Florinef） under IL-1β or TNF-α stimulation. Fludrocortisone was added to the culture medium at a concentration of 1 μg/μl, and 1 ng/μl of IL-1β or TNF-α was added at the same time. RESULTS Fludrocortisone reduced the expression of CCL2, IL-6, and IL-8 to baseline levels after TNF-α stimulation.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Mineralocorticoid Receptor, Fludrocortisone, Fludrocortisone acetate, Florinef, Astonin, 9α-Fludrocortisone, 9α-Fluorcortisol, 9α-fluorocortisol, 9α-fluorohydrocortisone, 9a-Fludrocortisone, 9a-Fluorcortisol, 9a-fluorocortisol, 9a-fluorohydrocortisone, 9alpha-Fludrocortisone, 9alpha-Fluorcortisol, 9alpha-fluorocortisol, 9alpha-fluorohydrocortisone

Compound Identifiers

PubChem CID

46781594