Fluconazole

SKU: orb1308762

Description

Fluconazole (UK-49858) is a triazole antifungal compound used in research to study fungal infections. It is widely applied in both in vitro assays and in vivo models to investigate its mechanism of action against pathogens like Candida and Cryptococcus.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 86386-73-4
• MW: 306.27
• Purity: 97.77% (May vary between batches)
• Formula: C₁₃H₁₂F₂N₆O
• SMILES: OC(CN1C=NC=N1)(CN1C=NC=N1)C1=C(F)C=C(F)C=C1
• Target: Antibiotic|||Antifection|||Antifungal
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.53 mM);Ethanol:30.6 mg/mL (99.91 mM);DMSO:260 mg/mL (848.92 mM)

Bioactivity

• In Vivo:
  Under physiological pH conditions, Fluconazole's activity against 35 Candida albicans strains is 16-fold lower than that of Ketoconazole. When used in combination with Amphotericin B, Fluconazole exhibits synergistic effects against C. albicans cells, yet it does not alter the anti-biofilm activity of AmB. Fluconazole, alongside Caspofungin, antagonizes biofilm formation but has no effect on planktonic cells. Significantly, Fluconazole reduces ergosterol levels in C. albicans planktonic cells, leading to membrane perturbation. Its activity is less sensitive to acidic conditions compared to Ketoconazole. Additionally, the combined use of Fluconazole and Itraconazole shows effective activity against various Candida species, including Fluconazole-resistant strains of C. albicans and Candida tropicalis.
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• In Vitro:
  Fluconazole significantly affects the fungicidal activity of 5-fluorocytosine against cryptococcal meningitis in mice. It is highly effective in extending the survival period of rats infected with representative Candida strains. Compared to the activity of each drug used alone, the combination of fluconazole with 5-fluorocytosine and amphotericin B exhibits markedly improved activity against cryptococcal meningitis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Fluconazole, Fungal, fungi,Candida, Inhibitor, inhibit, kefyr, albicans, Agent, 14-α Demethylase, Antifungal, Antibiotic, Candida, C. albicans, UK49858, UK-49858, UK 49858, Triazole

Compound Identifiers

PubChem CID

3365