FLT3-IN-41

SKU: orb3210757

Description

FLT3-IN-41 is a potent FLT3 inhibitor with IC50 values of 3.16 nM for human FLT3-ITD and 294.7 nM for FLT3-WT. It suppresses the STAT5, Akt, and Erk signaling pathways by binding to the ATP pocket of FLT3-ITD and FLT3-WT, forming hydrogen bonds with hinge region residues and Phe830. FLT3-IN-41 induces G2/M phase arrest and promotes apoptosis in FLT3-ITD positive acute myeloid leukemia cells, demonstrating significant antiproliferative activity. This compound serves as an important tool for the study of acute myeloid leukemia.

Key Properties

• Target: STAT,Akt,FLT,ERK,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

STAT,Akt,FLT,ERK,Apoptosis