FLT3-IN-34

SKU: orb3173246

Description

FLT3-IN-34 is an FLT3 inhibitor with an IC50 value of 1.4 nM. It inhibits the phosphorylation of FLT3 and downstream signaling molecules AKT and ERK1/2. In FLT3-ITD positive MV4-11 cells, FLT3-IN-34 induces concentration-dependent G0/G1 phase arrest and mild apoptosis (apoptosis). It exhibits potent antiproliferative activity against FLT3-ITD positive MV4-11 cells (IC50 = 14.95 nM) and MOLM-13 cells (IC50 = 18.5 nM). FLT3-IN-34 is useful for research on FLT3-positive acute myeloid leukemia (AML).

Key Properties

• CAS Number: 3020729-11-4
• MW: 417.47
• Formula: C₂₃H₂₃N₅O₃
• SMILES: O=C(NC1=NOC(=C1)C(C)(C)C)NC2=CC=C(C=C2)C(=O)C3=CN=C4C=C(C=CN43)C
• Target: Apoptosis,Akt,ERK,FLT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Apoptosis,Akt,ERK,FLT