FLT3-IN-32 hydrochloride

SKU: orb3136804

Description

FLT3-IN-32 hydrochloride is a potent, orally active FLT3 inhibitor with IC50 values of 0.29 nM for FLT3-ITD, 0.77 nM for FLT3-D835Y, and 2.07 nM for FLT3-N676K. It induces apoptosis in FLT3-mutant Ba/F3 cells by reducing the phosphorylation of FLT3 and its downstream signaling molecules (STAT5, MAPK, AKT). In MV4-11 xenograft models, it demonstrates significant antitumor effects. This compound is suitable for research in acute myeloid leukemia (AML).

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3047195-66-1
• MW: 552.02
• Formula: C₂₈H₃₀ClN₅O₅
• SMILES: Cl.O=C(NC1=NOC(=C1)C(C)(C)C)NC=2C=CC=3OC(=CC3C2)C(=O)C4=CC=5C(=CC=C(O)C5CN(C)C)N4
• Target: STAT,Akt,p38 MAPK,Apoptosis,FLT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

STAT,Akt,p38 MAPK,Apoptosis,FLT