FLT3-IN-28

SKU: orb2945340

Description

FLT3-IN-28 is an orally bioavailable FLT3 inhibitor that selectively targets FLT3-ITD mutations, demonstrating potent activity in AML cell lines like MV4-11 and MOLM-13 and inducing apoptosis. It shows significant in vivo efficacy, extending survival in MOLM-13 xenograft models, making it a valuable tool for FLT3-ITD+ cancer research.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• MW: 490.447
• Formula: C₂₃H₁₉FN₈O₄
• SMILES: C1C(CN1C(=O)NC2=NC=CC(=C2)OC3=C(C=C(C=C3)NC(=O)C4=CN(N=N4)C5=CN=CC=C5)F)O
• Target: FLT,Apoptosis,STAT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172677029