Flibanserin

SKU: orb1302975

Description

Flibanserin (Girosa) is a serotonergic agent approved for hypoactive sexual desire disorder. It is used in neuroscience research to study serotonin receptor modulation in vitro and in vivo. While minor serum enzyme elevations have been reported, it is not associated with clinically significant liver injury.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 167933-07-5
• MW: 390.4
• Purity: 99.93% (May vary between batches)
• Formula: C₂₀H₂₁F₃N₄O
• SMILES: C(CN1CCN(CC1)C2=CC(C(F)(F)F)=CC=C2)N3C=4C(NC3=O)=CC=CC4
• Target: Dopamine Receptor,5-HT Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.12 mM);DMSO:50 mg/mL (128.07 mM)

Bioactivity

• Target IC50:
  D4 receptor:4-24 nM(Ki)|5-HT2A:49 nM(Ki)|5-HT1A:1 nM(Ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

desire, disorder, DopamineReceptor, Dopamine Receptor, DP1, DP2, D4, 5-hydroxytryptamine Receptor, 5HTReceptor, affinity, 5-HT2A, 5-HT Receptor, 5-HT1A, 5HT Receptor, BIMT 17, BIMT17, BIMT-17, BIMT-17BS, antidepressant, antianxiety, Girosa, Flibanserin, Inhibitor, hypoactive, hypoactive sexual desire disorder, hippocampus, HSDD, midbrain, neurotransmitter, NHSF cell line, no cytotoxicity, orally active, inhibit, prefrontal cortex, sexual, Serotonin Receptor

Compound Identifiers

PubChem CID

6918248