Flavokawain B

SKU: orb1300239

Description

Flavokawain B is a bioactive chalcone from kava root with demonstrated anti-inflammatory and pro-apoptotic activities in vitro. It modulates NF-κB and MAPK pathways, inhibits inflammatory mediators like NO, and induces ROS-dependent apoptosis in various cancer cell lines, including prostate and colon cancers, supporting its research use in oncology and inflammation studies.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 1775-97-9
• MW: 284.31
• Purity: 99.97%
• Formula: C₁₇H₁₆O₄
• SMILES: COC1=CC(OC)=C(C(=O)\C=C\C2=CC=CC=C2)C(O)=C1
• Target: Caspase,MMP,ROS,PARP,Bcl-2 Family,Akt,PI3K,p38 MAPK,NF-κB,Apoptosis
• Solubility: DMSO:65 mg/mL (228.62 mM);Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Flavokavain B, Flavokawain B, Flavokawin B, Inhibitor, Apoptosis, 2'-Hydroxy-4',6'-Dimethoxychalcone

Compound Identifiers

PubChem CID

5356121