Flavokawain B (Standard)

SKU: orb3140043

Description

Flavokawain B (Standard) is a reference standard for research and analysis in studies involving Flavokawain B. 1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.

Key Properties

• CAS Number: 1775-97-9
• MW: 284.31
• Formula: C₁₇H₁₆O₄
• SMILES: COC1=CC(OC)=C(C(=O)\C=C\C2=CC=CC=C2)C(O)=C1
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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