Flavokawain B Dimer

SKU: orb3179466

Description

Flavokawain B Dimer has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. Flavokawain B Dimers the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.

Key Properties

• CAS Number: 2299-26-5
• MW: 568.62
• Formula: C₃₄H₃₂O₈
• SMILES: COc1cc(OC)c(C(CC(c2c(O)c(C(/C=C/c3ccccc3)=O)c(OC)cc2OC)c4ccccc4)=O)c(O)c1
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Others