（Iso）-Flavokawain A

SKU: orb1303413

Description

NSC-37445 demonstrates anti-tumor activity in models of bladder cancer, including inhibiting tumor growth and preventing recurrence in vivo. Its mechanism involves downregulating Myt1 and Wee1, leading to cyclin B1 accumulation and CDK1 activation in T24 cells. Flavokawain A exhibits anti-inflammatory effects by suppressing pro-inflammatory mediators via inhibition of NF-κB, AP-1, and MAPK signaling in macrophages.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Neuroscience, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 3420-72-2
• MW: 314.332
• Purity: 97.10% (May vary between batches)
• Formula: C₁₈H₁₈O₅
• SMILES: O=C(C=CC1=CC=C(OC)C=C1)C=2C(O)=CC(OC)=CC2OC
• Target: Histone Methyltransferase,Akt,NO Synthase,Survivin,IAP,ERK,p38 MAPK,Apoptosis,PI3K,COX,Cytochromes P450,Caspase,JNK
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble;DMSO:55 mg/mL (174.97 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (7.95 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Flavokavain A, Flavokawain A, EJ cells, Inhibitor, inhibit, bladder cancer, anticarcinogenic, Apoptotic, Apoptosis, chalcone, p38 MAPK, p38MAPK, p38, T24, tumor

Compound Identifiers

PubChem CID

235736