Flavanomarein

SKU: orb1297374

Description

Flavanomarein

Key Properties

• CAS Number: 577-38-8
• MW: 450.39
• Purity: 99.54% (May vary between batches)
• Formula: C₂₁H₂₂O₁₁
• SMILES: OC[C@H]1O[C@@H](Oc2ccc3C(=O)C[C@H](Oc3c2O)c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O
• Target: Others
• Solubility: DMSO:60 mg/mL (133.22 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.44 mM)

Bioactivity

• In Vitro:
  The present study aimed to identify the active compounds of Coreopsis tinctoria and to investigate the molecular mechanisms underlying its effects on lipid dysregulation by measuring lipid levels, reactive oxygen species, lipid peroxidation and fatty acid synthesis. The present results demonstrated that snow chrysanthemum aqueous extracts significantly reduced serum lipid levels and oxidative stress in vivo. The main compounds that were isolated were identified as Flavanomarein (compound 1) and eriodictyol 7-O-β-D glucopyranoside (compound 2). Compounds 1 and 2 demonstrated potent antioxidative properties, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells treated with free fatty acids (FFAs). Compound 2 was revealed to suppress the elevation of triglyceride levels and inhibit lipid peroxidation following FFA treatment. In addition, it was demonstrated to significantly reduce intracellular levels of reactive oxygen species and improve the mitochondrial membrane potential and adenosine triphosphate levels, thus protecting mitochondrial function in FFA-treated HepG2 cells. Furthermore, compound 2 markedly suppressed the protein expression levels of disulfide-isomerase A3 precursor and fatty acid synthase, thus suppressing FFA-induced lipogenesis in HepG2 cells

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Flavanomarein, Inhibitor, nephropathy, NF-κB, inhibit, antioxidative, anti-hyperlipidemic, antihypertensive, antidiabetic, AKT, 6-hydroxydopamine, diabetic, TGF-β1, Syk, Smad, PI3K

Compound Identifiers

PubChem CID

101781