FKK6

• Catalog Number: orb2814241
• Category: Small Molecules
• Description: FKK6 is a selective agonist of the pregnane X receptor (PXR) with an EC50 of 1.2 µM. It demonstrates strong affinity for plasma proteins and exhibits favorable metabolic characteristics in human microsomes. FKK6 inhibits the PXR-related NF-κB signaling pathway, reducing the expression of inflammatory factors and showing anti-inflammatory activity in a mouse model of DSS-induced colitis.
• MW: 402.47
• CAS Number: 2238839-34-2
• Formula: C₂₃H₁₈N₂O₃S
• SMILES: O=S(=O)(C=1C=CC=CC1)N2C=3C=CC=CC3C=C2C(O)(C=4C=CN=CC4)CC#C
• Storage: -20°C
• Note: For research use only