FKBP12 ligand-3

SKU: orb3135368

Description

FKBP12 ligand-3 (compound dj) is a high-affinity ligand targeting FKBP12. It is utilized to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching drugs intracellularly through the "CellTrap" effect to form an FKBP12-ligand-BRD4 ternary complex. This complex inhibits BRD4, reducing the expression of BRD4 target genes such as MYC, leading to tumor cell death. FKBP12 ligand-3 can be applied in selective cancer research based on differences in intracellular presenter protein levels.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 3036374-26-9
• MW: 536.47
• Formula: C₂₅H₂₇Cl₂N₃O₄S
• SMILES: S(=O)(=O)(N1[C@]2([C@@H](COCC#C)CN([C@@H](C)C3=CC=CC=N3)C(=O)[C@@]1(CCC2)[H])[H])C4=CC(Cl)=CC(Cl)=C4
• Target: FKBP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

FKBP