FKA-9i

SKU: orb3210237

Description

FKA-9i is an orally active anticancer agent that directly binds to and promotes the degradation of cancer-associated proteins LRPPRC (kd: 7.387 μM), YBX1 (kd: 16.52 μM), and RPN1 (kd: 26.82 μM). It inhibits the MAPK signaling pathway and mitochondrial oxidative phosphorylation. Additionally, FKA-9i induces cancer cell cycle arrest, apoptosis, mitochondrial dysfunction, and ROS accumulation, making it applicable in research on cancers such as gastric cancer.

Key Properties

• CAS Number: 3060515-85-4
• MW: 660.66
• Formula: C₃₀H₂₆F₂N₂O₉S₂
• SMILES: O=C1C2=C(OC)C=C(OC)C(=C2OC(C3=CC=C(OC)C(=C3)S(=O)(=O)NC4=CC=C(F)C=C4)C1)S(=O)(=O)NC5=CC=C(F)C=C5
• Target: Apoptosis,Caspase,ROS,CDK,p38 MAPK,Bcl-2 Family

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Caspase,ROS,CDK,p38 MAPK,Bcl-2 Family