FK 3311

SKU: orb1299978

Description

FK 3311 (COX-2 Inhibitor V) is an orally bioavailable, cell-permeable sulfonanilide and a selective cyclooxygenase-2 (COX-2) inhibitor. This NSAID is utilized in research to investigate inflammation, pain, and cancer mechanisms in both cellular and animal models.

Research Area

Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 116686-15-8
• MW: 341.33
• Purity: 97.30%
• Formula: C₁₅H₁₃F₂NO₄S
• SMILES: CC(=O)c1ccc(NS(C)(=O)=O)c(Oc2ccc(F)cc2F)c1
• Target: COX
• Solubility: DMSO:100 mg/mL (292.97 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.72 mM)

Bioactivity

• In Vivo:
  Survival rate was significantly better (p <0.05) and serum GOT levels 30 min after reperfusion were significantly lower (p <0.05) in the FK 3311(FK) high-dose group compared to the other two groups. Four hours after reperfusion, GPT levels and liver tissue flow were significantly (p <0.05) better in the FK high-dose group compared to the control. Both 30 min and 4 hr after reperfusion, serum TxB(2) levels were significantly lower in the FK high-dose group compared to the control (p <0.05).
• Animal Research:
  Inbred male Lewis rats weighing 200-260 g were used. The donor liver was perfused with cold University of Wisconsin (UW) solution and then stored in the same solution at 4 degrees C for 18 hr. After the preservation period, orthotopic liver transplantation was performed. Animals were divided into three groups: the control group; the FK low-dose group (1 mg/kg FK3311 i.v. 20 min before reperfusion); and the FK high-dose group (3 mg/kg FK3311. 20 min before reperfusion). Survival rate, serum GOT and GPT levels, liver tissue blood flow, and serum thromboxane B(2) (TxB(2)) levels were compared among groups.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclooxygenase, COX-2, COX-2 Inhibitor V, COX, inhibit, Inhibitor, FK 3311, FK3311, FK-3311

Compound Identifiers

PubChem CID

164009