FIP22

SKU: orb3175254

Description

FIP22 is a potent and selective IRAK4 PROTAC degrader with a DC50 of 3.2 nM in HEK293T cells and 10.6 nM in THP-1 cells. It induces the ubiquitin-proteasome system through the formation of an IRAK4-FIP22-CRBN ternary complex (EC50= 12.63 nM), effectively inhibiting the NF-κB and MAPK signaling pathways mediated by IRAK4. FIP22 is applicable for researching atopic dermatitis.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3091132-73-6
• MW: 838.97
• Formula: C₄₆H₅₀N₁₀O₆
• SMILES: C(=O)(N1CCC2(CCN(CC2)C=3C=C4C(=CC3)C(=O)N(C4=O)C5C(=O)NC(=O)CC5)CC1)[C@H]6CC[C@H](NC(=O)C=7C(NC(C)C)=CC(=NC7)N8C=9C(C=C8)=CC(C#N)=CN9)CC6
• Target: Interleukin,PROTACs,TNF,p38 MAPK,IRAK,NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Interleukin,PROTACs,TNF,p38 MAPK,IRAK,NF-κB