Finerenone

SKU: orb1306378

Description

Finerenone

Research Area

Metabolism Research

Key Properties

• CAS Number: 1050477-31-0
• MW: 378.42
• Purity: 99.72% (May vary between batches)
• Formula: C₂₁H₂₂N₄O₃
• SMILES: CCOc1ncc(C)c2NC(C)=C([C@@H](c3ccc(cc3OC)C#N)c12)C(N)=O
• Target: Glucocorticoid Receptor
• Solubility: DMSO:60 mg/mL (158.55 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:6 mg/mL (15.86 mM);H2O:Insoluble

Bioactivity

• Target IC50:
  CHO cells-K1 cells:16 nM|Mineralocorticoid receptor:18 nM|HEK293 cells:58 nM
• In Vivo:
  METHODS: To investigate the effects on vascular remodeling after acute vascular injury, Finerenone (1-10 mg/kg) was administered orally once daily for 21 days to wire-induced femoral artery dilated C57BL/6 mice. RESULTS: Finerenone treatment inhibited intimal and intermediate cell proliferation after wire-induced injury in mouse femoral arteries at 10 days post-injury and attenuated the formation of neoplastic intimal injury at 21 days post-injury.
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• In Vitro:
  METHODS: Human smooth muscle cells SMC and human endothelial cells EC were treated with aldosterone (1-50 nM) and Finerenone (1-10 nM) for 24 h. Cell proliferation was detected by BrdU incorporation assay. RESULTS: After stimulation with aldosterone, the proliferation rate of SMC increased significantly. Although treatment with 1 nM concentration of Finerenone showed a clear tendency to decrease the SMC proliferation rate, 10 nM Finerenone adequately and significantly blocked aldosterone-induced SMC proliferation. However, aldosterone did not affect EC proliferation in vitro, nor did Finerenone. METHODS: HK-GFP-hMR cells were treated with aldosterone (10 nM) and Finerenone (1 µM) for 3 h. The gene expression levels were measured by RT-qPCR. RESULTS: Finerenone was effective in antagonizing some aldosterone-induced genes.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

disease, diabetes, cardiorenal, chronic, BAY 948862, BAY 94-8862, BAY948862, BAY-948862, BAY-94-8862, BAY94-8862, blood, Glucocorticoid Receptor, GlucocorticoidReceptor, Finerenone, Inhibitor, kidney, nonsteroidal, inhibit, oral, Mineralocorticoid Receptor, type, systolic, pressure

Compound Identifiers

PubChem CID

60150535