Filipin complex

SKU: orb1992856

Description

Filipin complex is a 28-membered macrolide antifungal antibiotic produced by Streptomyces species. It inhibits PRRSV viral entry into host cells and is widely used in research to study cholesterol-dependent membrane processes and viral infection mechanisms in vitro.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 11078-21-0
• MW: 1916.517
• Purity: 98.00% (May vary between batches)
• Formula: C₁₀₅H₁₇₄O₃₀
• SMILES: CCCCCC[C@@H]1[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)\C(C)=C\C=C\C=C\C=C\C=C\C[C@@H](C)OC1=O.CCCCCC[C@@H]1[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)\C(C)=C\C=C\C=C\C=C\C=C\[C@H](O)[C@@H](C)OC1=O.CCCCC[C@@H](O)[C@@H]1[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)\C(C)=C\C=C\C=C\C=C\C=C\[C@H](O)[C@@H](C)OC1=O |t:28,30,32,34,36,72,74,76,78,80,118,120,122,124,126|
• Target: Antifungal,Antibiotic
• Solubility: DMSO:100 mg/mL;Ethanol:25 mg/mL;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL

Bioactivity

• In Vitro:
  Filipin complex (2 μg/mL; 1+48 hours) can inhibit the entry of PRRSV. The genomic copies of PRRSV in infected MARC-145 cells decreased by 61% .

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Filipin complex, Fungal

Quick Database Links

Gene Symbol

Antifungal,Antibiotic