Filibuvir

SKU: orb1707311

Description

Filibuvir (PF-00868554) is a potent, noncovalent inhibitor of the hepatitis C virus NS5B RNA-dependent RNA polymerase. It demonstrates antiviral activity against HCV genotypes 1a and 1b in replicon assays with EC50 values of 59 nM. This compound is a valuable tool for investigating HCV replication mechanisms and evaluating antiviral strategies in vitro.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 877130-28-4
• MW: 503.64
• Purity: 98.76% (May vary between batches)
• Formula: C₂₉H₃₇N₅O₃
• SMILES: CCc1cc(CC[C@@]2(CC(O)=C(Cc3nc4nc(C)cc(C)n4n3)C(=O)O2)C2CCCC2)cc(CC)n1
• Target: DNA/RNA Synthesis,HCV Protease
• Solubility: DMSO:40 mg/mL (79.42 mM)

Bioactivity

• In Vitro:
  In Huh7.5 cells, Filibuvir (0.01-10000 nM; 48 h) dose-dependently inhibits the WT 1b replicon with EC50s of ∼70 nM. Filibuvir decreases primer extension from PE46 with an IC50 of 73 nM, but has no obvious effect on de novo-initiated RNA synthesis with IC50 of 5 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RNA Synthesis, RNA-dependent RNA polymerase, RNASynthesis, PF-00868554, PF00868554, PF 00868554, DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, HCV NS5B, HCVProtease, HCV Protease, Filibuvir

Compound Identifiers

PubChem CID

54708673