FIDAS-3

SKU: orb1218973

Description

FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities. FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A).

Key Properties

• CAS Number: 1266684-01-8
• MW: 259.29
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₅F₂N
• SMILES: CN(C)C1=CC=C(/C=C/C2=C(F)C=CC=C2F)C=C1
• Target: Wnt/beta/catenin
• Solubility: DMSO:90mg/ml(347.10mM; Need ultrasonic)

Bioactivity

• In Vivo:
  FIDAS-3 (20 mg/kg; intraperitoneal injection; daily; for one months; C57BL/6J athymic nude mice) treatment significantly inhibits the growth of xenograft tumors. Animal model: C57BL/6J athymic nude mice (6-8 week) injected with LS174 cells. Dosage: 20 mg/kg. Administration: Intraperitoneal injection; daily; for one months. Result: Significantly inhibited the growth of xenograft tumors.
• In Vitro:
  FIDAS-3 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells. FIDAS-3 (3-10 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. And FIDAS-3 induces the expression of cell cycle inhibitor, p21WAF1/CIP1. FIDAS-3 (10 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosyl homocysteine (SAH) in LS174T cells. Cell Viability Assay Cell line: LS174T colorectal cancer (CRC) cells. Concentration: 3 μM. Incubation time: 7 days. Result: Significantly inhibited the proliferation of LS174T cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Wnt/beta/catenin