FH-535

SKU: orb1305521

Description

FH535 is a dual inhibitor of Wnt/β-catenin signaling and PPARγ/δ, demonstrating anti-proliferative and anti-tumor effects in research. It is utilized in vitro and in vivo for studying oncogenesis, metabolic pathways, and as a potential therapeutic agent in cancers such as colorectal and hepatocellular carcinoma.

Research Area

Metabolism Research, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 108409-83-2
• MW: 361.21
• Purity: >98%
• Formula: C₁₃H₁₀Cl₂N₂O₄S
• SMILES: Cc1cc(ccc1NS(=O)(=O)c1cc(Cl)ccc1Cl)[N+]([O-])=O
• Target: PPAR
• Solubility: Soluble in DMSO (up to 25 mg/ml).

Bioactivity

• In Vivo:
  FH535 inhibits β-catenin/Tcf-mediated transcription and also suppresses the aggregation of co-activator GRIP1 and β-catenin with PPARδ and PPARγ. In cancer cells with elevated or active Wnt/β-catenin pathways, FH535 can inhibit cell proliferation.
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• Cell Research:
  Cell viability is determined by the modified 3H-thymidine incorporation assay. Briefly, cells are plated in 96-well microplates for 24 h and treated in triplicate with various concentrations of the test compound. After 48 h of compound exposure, the cells are incubated for an additional 48 h in compound-free medium. The cells are then incubated in medium containing 3H-thymidine for 24 h, washed and mixed with the scintillant in the 96-well plate. Individual wells are counted with a 96-well scintillation counter and the LC50 is calculated.(Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, FH 535, FH535, FH-535, Inhibitor, bcatenin, Beta catenin, beta-catenin, betacatenin, PPARγ, PPARδ, Peroxisome proliferator-activated receptors, PPAR, Wnt/β-catenin, Wnt/betacatenin, Wnt/b-catenin, Wnt, β-catenin, βcatenin

Compound Identifiers

PubChem CID

3463933