FGFR4-IN-8

SKU: orb1744416

Description

FGFR4-IN-8 is a highly selective, ATP-competitive covalent inhibitor effective against wild-type and gatekeeper mutant FGFR4 (IC50: 0.5-1.6 nM). It demonstrates potent antiproliferative activity in Hep3B cells (IC50: 29 nM) and shows moderate antitumor efficacy in Huh-7 xenograft models, supporting its use in FGFR4-driven cancer research.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2765240-52-4
• MW: 654.56
• Formula: C₃₂H₃₄Cl₂FN₇O₃
• SMILES: C[C@H](C1=C(C=NC=C1Cl)Cl)OC2=CC3=C(C=C2)NN=C3NC4=C(C=C(C=C4F)N5CCC(CC5)N6CCOCC6)NC(=O)C=C
• Target: FGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

163322307