FGFR4-IN-24

SKU: orb3174663

Description

FGFR4-IN-24 is a selective irreversible covalent inhibitor of FGFR4 with an IC50 of 1.2 nM. It demonstrates significantly weaker activity against the other three FGFR family kinases (FGFR1-3). FGFR4-IN-24 effectively inhibits the FGF19/FGFR4 signaling pathway, suppressing the proliferation of the HuH-7 hepatocellular carcinoma cell line (GI50= 17 nM). In HuH-7 mouse xenograft models, FGFR4-IN-24 shows notable antitumor activity. This compound is applicable for hepatocellular carcinoma research.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 3053546-73-6
• MW: 483.5
• Formula: C₂₇H₂₂FN₅O₃
• SMILES: O=C(C=C)NC=1C=CC=CC1NC2=NC=3NC=C(C(=O)C4=CC(=CC=C4F)C(=O)NC5CC5)C3C=C2
• Target: FGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

FGFR