FGFR2/3-IN-3

SKU: orb3135375

Description

FGFR2/3-IN-3 is a dual-target FGFR2/3 inhibitor with IC50 values of 2.7 nM (TEL-FGFR2) and 3.9 nM (TEL-FGFR3), displaying efficacy against both wild-type and mutant FGFR3. It exhibits low CYP3A4 inhibition and minimal hERG toxicity. By inhibiting mutant FGFR3-mediated pathways, FGFR2/3-IN-3 improves chondrocyte proliferation and differentiation imbalances, promoting bone growth. In a dwarfism mouse model, it demonstrates growth-promoting effects, indicating potential for treating bone development disorders such as achondroplasia (ACH).

Research Area

Cardiovascular Research, Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 3069945-78-1
• MW: 569.46
• Formula: C₂₈H₂₇Cl₂FN₆O₂
• SMILES: O([C@H](C)C=1C(Cl)=CN=CC1Cl)C=2C=C3C(=NNC3=CC2C)C=4C=C(F)C(=NC4)C5=CN(CC(C)(C)O)N=C5C
• Target: Cytochromes P450,FGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Cytochromes P450,FGFR