FGFR2/3-IN-2

SKU: orb2944393

Description

FGFR2/3-IN-2 is a potent and selective oral inhibitor of FGFR2 (IC50=3.7 nM) and FGFR3 (IC50=31.2 nM). It demonstrates antitumor efficacy, including stasis and regression, in models like SNU-16 gastric cancer, without inducing common on-target toxicities such as hyperphosphatemia or diarrhea in vivo.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3025799-28-1
• MW: 522.53
• Formula: C₂₉H₂₃FN₆O₃
• SMILES: O=C(N)C1=C2C=NC(=CN2C(C=3C=CC(=CC3)NC(=O)C(F)=C)=C1C4=CC=C(OC5=NC=CC(=N5)C)C=C4)C
• Target: FGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176455398