FGFR-IN-23

SKU: orb3173065

Description

FGFR-IN-23 (Compound 9p) is a covalent pan-FGFR inhibitor with IC50 values of 14 nM, 4.2 nM, 5 nM, and 220 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. It also effectively inhibits gatekeeper gene mutants such as FGFR1V561M and FGFR3V555M. FGFR-IN-23 suppresses FGFR-mediated signaling activation and induces apoptosis. In RT112 xenograft mouse models, FGFR-IN-23 demonstrates significant antitumor efficacy. It is applicable for research in cancer and its drug resistance.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• Target: Apoptosis,FGFR,Akt,ERK,p38 MAPK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,FGFR,Akt,ERK,p38 MAPK