FGF/PDGF/VEGF RTK Inhibitor

SKU: orb1737550

Description

This small molecule is a potent, ATP-competitive inhibitor targeting PDGFRβ, FGFR1, and VEGFR2 with respective IC50 values of 20, 90, and 240 nM. It reversibly inhibits VEGF-driven proliferation in HMVECs (EC50 = 420 nM) and is a valuable tool for studying angiogenesis and tumor growth in both cellular and animal models.

Research Area

Cardiovascular Research; Stem Cell & Developmental Biology; Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	144335-37-5
MW	277.28
Formula	C₁₆H₁₁N₃O₂
SMILES	OC1=C(C(=O)NC=2C1=CC=CC2)C=3NC=4C(N3)=CC=CC4
Target	Others

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

135433815 ↗

Key Properties

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No computed properties available.

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