FGF/PDGF/VEGF RTK Inhibitor

SKU: orb1737550

Description

This small molecule is a potent, ATP-competitive inhibitor targeting PDGFRβ, FGFR1, and VEGFR2 with respective IC50 values of 20, 90, and 240 nM. It reversibly inhibits VEGF-driven proliferation in HMVECs (EC50 = 420 nM) and is a valuable tool for studying angiogenesis and tumor growth in both cellular and animal models.

Research Area

Cardiovascular Research; Stem Cell & Developmental Biology; Pharmacology & Drug Discovery

Key Properties

• CAS Number: 144335-37-5
• MW: 277.28
• Formula: C₁₆H₁₁N₃O₂
• SMILES: OC1=C(C(=O)NC=2C1=CC=CC2)C=3NC=4C(N3)=CC=CC4
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

135433815