Ferroptosis inducer-9

SKU: orb3173330

Description

Ferroptosisinducer-9 is an agent that induces ferroptosis and acts as a microtubule polymerization inhibitor at the colchicine binding site. It inhibits MCF-7 cell growth with an IC50 of 14 nM and reduces [3H]colchicine binding. The compound decreases GPX4 and FTH expression while increasing COX2 and ACSL4 levels; it also lowers GSH, NADP+, and NADPH, and raises LPO, MDA, and Fe(II) concentrations, alongside reducing SOD levels. Ferroptosisinducer-9 demonstrates significant antitumor efficacy in HCT116 CRC xenograft models and is applicable in the study of triple-negative breast cancer (TNBC) and colorectal cancer (CRC).

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction

Key Properties

• Target: Glutathione Peroxidase,Ferroptosis,Microtubule Associated,COX

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Glutathione Peroxidase,Ferroptosis,Microtubule Associated,COX