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Ferroptosis inducer-11

SKU: orb3173199

Description

Ferroptosisinducer-11 is an agent that induces ferroptosis, exhibiting significant cytotoxicity against HCT-116, NCM-60, and HT-29 cells with IC50 values of 0.43 μM, 3.14 μM, and 0.48 μM, respectively. It potently inhibits GPX4 enzyme activity with an IC50 of 1.86 μM. This compound induces ferroptosis and increases lipid ROS, malondialdehyde (MDA), and Fe2+ levels in colon cancer cells while reducing glutathione (GSH) levels. Ferroptosisinducer-11 is useful for colon cancer research.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research

Images & Validation

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Ferroptosis inducer-11

Key Properties

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TargetROS,Glutathione Peroxidase,Ferroptosis

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Quick Database Links

Gene Symbol
ROS,Glutathione Peroxidase,Ferroptosis

Protocol Information

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