Ferroptosis-IN-21

SKU: orb3173847

Description

Ferroptosis-IN-21 is an inhibitor of ferroptosis that combats renal ischemia-reperfusion injury by directly scavenging peroxy free radicals to prevent cell death. It demonstrates broad-spectrum, nanomolar-level inhibitory potency against various ferroptosis inducers in renal tubular epithelial cells and effectively suppresses the accumulation of lipid reactive oxygen species (ROS). Additionally, Ferroptosis-IN-21 significantly alleviates renal ischemia-reperfusion injury in mice, as evidenced by improved histological damage and functional impairment, reduced expression of inflammatory cytokines, and decreased levels of lipid peroxidation biomarkers such as 4-hydroxynonenal. Ferroptosis-IN-21 is a potential candidate in research for developing ferroptosis-targeted therapeutics.

Key Properties

• CAS Number: 6640-50-2
• MW: 149.19
• Formula: C₉H₁₁NO
• SMILES: OC1=CC=CC2=C1NCCC2
• Target: Ferroptosis,ROS

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Ferroptosis,ROS