Fenoterol hydrobromide

SKU: orb1704827

Description

Fenoterol hydrobromide is a selective β2-adrenergic receptor agonist used as a bronchodilator in research. It is widely applied in studies of asthma and COPD, facilitating investigations into bronchial smooth muscle relaxation and receptor signaling in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1944-12-3
• MW: 384.27
• Purity: 99.88% (May vary between batches)
• Formula: C₁₇H₂₂BrNO₄
• SMILES: Br.OC1=CC=C(C=C1)CC(NCC(O)C=2C=C(O)C=C(O)C2)C
• Target: Adrenergic Receptor
• Solubility: DMSO:80 mg/mL (208.19 mM);H2O:20 mg/mL (52.05 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.59 mM)

Bioactivity

• In Vivo:
  0.7 mg/kg Fenoterol hydrobromide injected intraperitoneally twice daily was treated to suppress mechanically abnormal pain during chronic treatment.
• In Vitro:
  Fenoterol hydrobromide inhibited lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells. Fenoterol hydrobromide treatment reduced AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly down-regulated the elevated phosphorylation level of AMPK. Fenoterol hydrobromide is a potent activator of exosome biogenesis and/or secretion in PC cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Adrenergic Receptor, AdrenergicReceptor, Fenoterol Hydrobromide, β2-adrenoceptor, β2 adrenoreceptor

Compound Identifiers

PubChem CID

5702161