Fenofibrate

SKU: orb1309601

Description

Fenofibrate

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 49562-28-9
• MW: 360.83
• Purity: >99.99% (May vary between batches)
• Formula: C₂₀H₂₁ClO₄
• SMILES: C(=O)(C1=CC=C(OC(C(OC(C)C)=O)(C)C)C=C1)C2=CC=C(Cl)C=C2
• Target: Cytochromes P450,Autophagy,PPAR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5.5 mg/mL (15.24 mM);Ethanol:36.1 mg/mL (100.05 mM);DMSO:100 mg/mL (277.14 mM)

Bioactivity

• Target IC50:
  CYP2C9:9.7 μM|CYP2C8:4.8 μM|CYP2B6:0.7 μM|CYP3A4:142.1 μM|PPARα:30 μM(EC50)|CYP2C19:0.2 μM
• In Vivo:
  METHODS: To test the antitumor activity in vivo, LCL161 (50 mg/kg twice daily) and PKC412 (40 mg/kg once daily) were administered by gavage to NCr nude mice injected with Ba/F3-FLT3-ITD-luc+ tumor cells for seven days. RESULTS: LCL161 significantly enhanced the ability of PKC412 to inhibit the growth of Ba/F3-FLT3-ITD-luc+ cells in vivo. the difference between the inhibition of leukemia growth by PKC412 or LCL161 alone and the combined inhibition of leukemia growth by PKC412+LCL161 was also significant. The weight of spleens of mice treated with PKC412+LCL161 percentage was less than that of mice treated with vector alone or either drug.
• In Vitro:
  METHODS: MOLM13 cells were treated with LCL161 (1000-160000 nM) and PKC412 (2.5-40 nM) for 3 days, and cell viability was measured by trypan blue exclusion. RESULTS: LCL161 moderately inhibited cell growth when administered alone. the combination of LCL161 and PKC412 killed significantly more MOLM13-luc+ cells than either drug alone, and the Calcusyn Combination Index suggests a synergistic effect. METHODS: NSCLC cells A549 and H460 were treated with LCL161 (10 µM) and paclitaxel (10 µM) for 48 h and apoptosis was detected by flow cytometry. RESULTS: Apoptosis was significantly reduced in the LCL161/paclitaxel combination treatment group compared to cells treated with LCL161 or paclitaxel alone.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Peroxisome proliferator-activated receptors, PPARα, PPAR, Procetofen, Cytochrome P450, CYP2B6, CYP2C, CYP2C19, CYPs, Autophagy, inhibit, Lipanthyl, Lipantil, Inhibitor, Fenofibrate

Compound Identifiers

PubChem CID

3339