Fenobam

SKU: orb1308308

Description

Fenobam is a selective, non-competitive allosteric antagonist and inverse agonist of mGluR5, with high affinity for both rat and human receptors. It exhibits anxiolytic properties and is widely used in neuroscience research to investigate receptor function in models of anxiety, Fragile X syndrome, and neuropsychiatric disorders.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 57653-26-6
• MW: 266.68
• Purity: 99.93% (May vary between batches)
• Formula: C₁₁H₁₁ClN₄O₂
• SMILES: CN1CC(=O)N=C1NC(=O)Nc1cccc(Cl)c1
• Target: Apoptosis,GluR
• Solubility: DMSO:55 mg/mL (206.24 mM)

Bioactivity

• Target IC50:
  mGluR5 (rat):54 nM (Kd)|mGluR5 (human):31 nM (Kd)|mGluR5:84 nM
• In Vivo:
  Fenobam sulfate (30-60 mg/kg; p.o.) significantly inhibited cocaine self-administration .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cocaine, brain-penetrant, anxiolytic, addiction, nonbenzodiazepine, inhibit, Metabotropic glutamate receptors, mGluR, mGluR5 (Human), mGluR5 (Rat), human mGluR5, Fenobam, Inhibitor, rat mGluR5

Compound Identifiers

PubChem CID

135497698