FCN-338

SKU: orb3136031

Description

FCN-338 (LOXO-338) is an orally active and selective Bcl-2 inhibitor, exhibiting an IC50 of 4.5 nM for the Bcl-2/BAK interaction. It effectively suppresses tumor growth in mouse models of follicular lymphoma (FL), acute myeloid leukemia (AML), and acute lymphoblastic leukemia (ALL) xenografts without causing significant weight loss. FCN-338 demonstrates broad-spectrum anticancer activity, making it suitable for treating FL, chronic lymphocytic leukemia (CLL)/small lymphocytic leukemia (SLL), AML, and ALL.

Research Area

Cell Biology

Key Properties

• CAS Number: 2248046-39-9
• MW: 902.46
• Formula: C₄₈H₄₈ClN₇O₇S
• SMILES: N(=O)(=O)C1=C2C(=CC(S(NC(=O)C3=C(OC=4C=C5C(=NC4)NC=C5)C=C(C=C3)N6CCN(CC7=C(CC(C)(C)CC7)C8=CC=C(Cl)C=C8)CC6)(=O)=O)=C1)OC[C@H](CC9=CC=CC=C9)N2
• Target: Bcl-2 Family

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Bcl-2 Family