FAUC-365

SKU: orb1306245

Description

FAUC-365 is a selective agonist for the dopamine D3 receptor. It is a valuable research tool for investigating D3 receptor function in neuropharmacology, with applications in both in vitro binding assays and in vivo models of addiction and neurological disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 474432-66-1
• MW: 462.44
• Purity: 99.62% (May vary between batches)
• Formula: C₂₃H₂₅Cl₂N₃OS
• SMILES: Clc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4s3)CC2)c1Cl
• Target: Dopamine Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.32 mM);DMSO:50 mg/mL (108.12 mM);EtOH:insoluble;H2O:insoluble

Bioactivity

• Target IC50:
  5-HT:0.50 nM(Ki)
• In Vitro:
  As a dichloro derivative, FAUC-365 revealed D3 affinities that were comparable to its methoxy-substituted analogs, however, the selectivities of FAUC-365 against 5HT-1A, 5-HT2, and R1 were substantially higher, which was demonstrated by the extraordinary selectivity ratios of 17600, 7200, 5200, and 680 over D1, D2long, D2short, and D4, respectively, were determined for FAUC-365 with Ki of 0.50 nM. In addition, the benzothiophene analog FAUC 346 and its oxa analog showed partial agonist character with EC50 values at 0.36 and 1.5 nM, respectively .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

D3 receptor, D3, Dopamine, Dopamine Receptor, DopamineReceptor, FAUC 365, FAUC365, FAUC-365, FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide, FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide, Inhibitor, Parkinson's disease, inhibit, schizophrenia, SPET, Radioligand

Compound Identifiers

PubChem CID

10276451