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Fasudil dihydrochloride
Catalog Number: orb1688655
| Catalog Number | orb1688655 |
|---|---|
| Category | Small Molecules |
| Description | Fasudil dihydrochloride |
| CAS Number | 203911-27-7 |
| Purity | 98% |
| MW | 364.29 |
| SMILES | Cl.Cl.O=S(=O)(N1CCCNCC1)c1cccc2cnccc12 |
| Formula | C14H19Cl2N3O2S |
| Biological Activity | Fasudil dihydrochloride, also known as HA-1077 and AT877, is a nonspecific inhibitor of RhoA/ROCK. It exhibits inhibitory effects on protein kinases, including ROCK1 with a Ki value of 0.33 μM, as well as ROCK2, PKA, PKC, and PKG with IC 50 values of 0.158 μM, 4.58 μM, 12.30 μM, and 1.650 μM, respectively. Additionally, Fasudil dihydrochloride demonstrates potent Ca 2+ channel blocking activity and acts as a vasodilator [1] [2] [3]. |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
