Fasnall HCl

SKU: orb1737828

Description

Fasnall HCl is a selective fatty acid synthase (FASN) inhibitor that targets the enzyme's co-factor binding sites. It demonstrates significant anti-tumor efficacy in preclinical models, including the MMTV-Neu mouse model of HER2-positive breast cancer, particularly in combination with carboplatin. This small molecule is a valuable research tool for studying lipid metabolism in oncology.

Research Area

Metabolism Research

Key Properties

• MW: 374.93
• Purity: 90.00% (May vary between batches)
• Formula: C₁₉H₂₃ClN₄S
• SMILES: CC1=C(C)SC2=NC=NC(NC3CN(CC3)CC4=CC=CC=C4)=C21.Cl
• Target: Fatty Acid Synthase
• Solubility: DMSO:22.5 mg/mL (60.01 mM)

Bioactivity

• Target IC50:
  FASN:3.71 μM
• In Vivo:
  FVB/J mice received 5, 20, or 80 mg/kg Fasnall HCl via intraperitoneal injection on days 1 and 3. Fasnall HCl was toxic at 80 mg/kg, but at 5–20 mg/kg was well tolerated with no adverse effects on white blood cell counts, hemoglobin levels, kidney, or liver functions. Cohorts of MMTV-Neu mice were treated with a biweekly intraperitoneal injection of 15 mg/kg Fasnall HCl, shows that Fasnall HCl reduced tumor volume compared with vehicle-treated animals .
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• In Vitro:
  Fasnall HCl potently blocked both acetate and glucose incorporation into total lipids, with IC50 values of 147 and 213 nM, respectively, in HepG2 cells. Fasnall HCl inhibited FASN with IC50 values of 3.71 μM in vitro. The molecules were tested in the acetate incorporation assay in BT474 cells. Fasnall HCl is able to inhibit the incorporation of tritiated acetate (IC50 5.84 μM, respectively) into lipids .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

929978-58-5, 929978-58-5 Free base, FattyAcidSynthase, Fatty Acid Synthase (FASN), Fatty Acid Synthase, Fasnall HCl, Fasnall HCl(929978-58-5 Free base)

Compound Identifiers

PubChem CID

169553386