Famciclovir

SKU: orb1227074

Description

A guanine analogue antiviral agent used for the treatment of various herpesvirus (HSV) infections. HSV Infection Approved(In Vitro):Famciclovir metabolizes into BRL 42359 by deacetylation and then oxidizes to penciclovir.(In Vivo):Famciclovir (50-400 mg/kg; p.o. three times per day for total 10 doses) effectively cures necrotic hepatitis mice.

Key Properties

• CAS Number: 104227-87-4
• MW: 321.3318
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₉N₅O₄
• SMILES: CC(OCC(COC(C)=O)CCN1C=NC2=CN=C(N)N=C12)=O
• Target: HSV
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  Famciclovir (50-400 mg/kg; p.o. three times per day for total 10 doses) effectively cures necrotic hepatitis mice. Animal model: Four-to five-week-old Balb/c mice with HSV-1 infection. Dosage: 50, 100, 200 and 400 mg/kg. Administration: Oral gavage; 50-400 mg/kg per day divided into three doses given every 8 h; for total 10 doses. Result: Significantly reduced the incidence of hepatitis with a dose of 50 mg/kg per day, and could not isolated infectious virus from the doses of 50 and 100 mg/kg treatment group.
• In Vitro:
  Famciclovir metabolizes into BRL 42359 by deacetylation and then oxidizes to penciclovir.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRL-42810

Quick Database Links

Gene Symbol

HSV