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FAK-IN-22

SKU: orb2814238

Description

FAK-IN-22 (Compound 26) is a potent multi-kinase inhibitor targeting FAK, JAK3, and Aurora B (IC50s: 50.94, 9.99, and 0.49 nM, respectively). It suppresses pancreatic cancer (PDAC) proliferation, metastasis, and tumorigenesis in vitro and in vivo by inducing apoptosis and G2/M arrest via FAK/PI3K/Akt pathway inhibition.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

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Key Properties

CAS Number2703920-02-7
MW427.38
FormulaC21H16F3N5O2
SMILESO=C(NC)C1=CC=C(C=C1)NC2=NC=C(C(=N2)OC3=CC=CC=4NC=CC34)C(F)(F)F
TargetJAK,Apoptosis,FAK,Aurora Kinase,Akt,PI3K

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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FAK-IN-22 (orb2814238)

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