FA16

SKU: orb1819238

Description

FA16 is a selective and metabolically stable 2-(trifluoromethyl)benzimidazole derivative that potently induces ferroptosis by inhibiting system Xc- (IC50 = 1.26 μM). It blocks cystine/glutamate exchange, leading to glutathione depletion and lipid peroxidation. This compound has demonstrated significant antitumor efficacy in a HepG2 xenograft model, supporting its use in researching ferroptosis-dependent cancer therapies.

Research Area

Cell Biology

Key Properties

• MW: 468.54
• Purity: 99.81% (May vary between batches)
• Formula: C₂₂H₂₇F₃N₄O₂S
• SMILES: FC(F)(F)C(N=C1C2C=CC=C1)N2CC(CC3)CCN3C4=CC=C(S(N(C)C)(=O)=O)C=C4
• Target: Ferroptosis
• Solubility: DMSO:4.69 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  Ferroptosis (HT1080 cells):1.26 μM
• In Vivo:
  FA16 (15 or 30 mg/kg; intraperitoneal injection; every other day for 21 days; BALB/c nude mice bearing HepG2 tumors (subcutaneously)) significantly inhibited tumor growth in a 786-O xenograft mouse model, with TGI values of 47.6% and 77.1%, respectively.FA16 was safe (did not induce body weight loss), and it also induced tumor tissue iron death occurred.
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• In Vitro:
  FA16 (15 or 30 mg/kg; intraperitoneal injection; every other day for 21 days; BALB/c nude mice bearing HepG2 tumors (subcutaneously)) significantly inhibited tumor growth in a 786-O xenograft mouse model, with TGI values of 47.6% and 77.1%, respectively.FA16 was safe (did not induce body weight loss), and it also induced tumor tissue iron death occurred.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FA-16, FA16, FA 16, Ferroptosis

Compound Identifiers

PubChem CID

171360726