F5446

• Catalog Number: orb1737604
• Category: Small Molecules
• Description: F5446
• Purity: 98.56%
• MW: 552.94
• Biological Activity: F5446 is a SUV39H1 inhibitor. F5446 has an EC50 of 0.496 μmol/L for SUV39H1 enzymatic activity. H3K9me3 was enriched in the promoters of GZMB, PRF1, FASLG, and IFNG in quiescent T cells. F5446 inhibited H3K9me3, thereby upregulating expression of these effectors in tumor-infiltrating CTLs and suppressing colon carcinoma growth in a CD8+ CTL-dependent manner in vivo. Our data indicate that SUV39H1 represses CTL effector gene expression and, in doing so, confers colon cancer immune escape.
• CAS Number: [2304465-89-0]
• Formula: C₂₆H₁₇ClN₂O₈S
• SMILES: COC(=O)c1cc2-c3c(c[nH]c3C(=O)C(=O)c2n1S(=O)(=O)c1ccc(Cl)cc1)C(=O)OCc1ccccc1
• Storage: -20°C
• Note: For research use only