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F44-S101

SKU: orb3211382

Description

F44-S101 is an orally active, potent, and selective intestine-restricted FXR antagonist with an IC50 of 0.48 μM, exhibiting lipid-lowering effects. It selectively antagonizes intestinal FXR, which in turn activates hepatic FXR feedback, promoting cholesterol metabolism and reducing lipid accumulation. F44-S101 effectively lowers total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, making it suitable for research related to hyperlipidemia.

Images & Validation

Key Properties

TargetFXR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

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Protocol Information