F44-A13

SKU: orb2566288

Description

F44-A13 is a potent and selective oral FXR antagonist (IC50 = 1.1 µM) that modulates lipid metabolism. It upregulates CYP7A1, leading to reduced cholesterol, triglycerides, and LDL-C in mouse models, making it a valuable research tool for studying dyslipidemia and related metabolic disorders.

Research Area

Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 1338190-14-9
• MW: 544.71
• Formula: C₂₈H₄₀N₄O₅S
• SMILES: C(N(CC1CC1)C(NC(C)(C)C)=O)C2=C(OS(=O)(=O)C3=CC=C(NC(C)=O)C=C3)C=C(N(CC)CC)C=C2
• Target: Cytochromes P450,Retinoid Receptor,FXR,ROR,PPAR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

83279418