F13714 fumarate

SKU: orb1692733

Description

F13714 fumarate is a biased agonist selective for the 5-HT1A receptor. A single administration demonstrates antidepressant-like effects in a chronic mild stress mouse model. This compound is a research tool for studying serotonin signaling in depression and anxiety, applicable in both in vitro binding assays and in vivo behavioral studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 208109-39-1
• MW: 538.97
• Purity: 98.86%
• Formula: C₂₅H₂₉ClF₂N₄O₅
• SMILES: C(=C/C(O)=O)\C(O)=O.C(=O)(N1CCC(CNCC=2N=C(NC)C(C)=CC2)(F)CC1)C3=CC(Cl)=C(F)C=C3
• Target: 5-HT Receptor
• Solubility: DMSO:200 mg/mL (371.08 mM)

Bioactivity

• In Vivo:
  METHODS: F13714 fumarate (1, 2, 4, 8, 16 mg/kg, oral) was administered to mice, and the antidepressant-like properties of the compound and its effects on cognitive function were evaluated using the forced swim test (FST) and novel object recognition (NOR), respectively; the depressive-like state was induced by the unpredictable chronic mild stress (UCMS) procedure to test the activity of F13714 fumarate in the depression model, and then sucrose preference, FST and locomotor activity were measured. The levels of phosphorylated cyclic AMP response element binding protein (p-CREB) and phosphorylated extracellular signal-regulated kinase (p-ERK1/2) were also determined. RESULTS: F13714 fumarate (2 and 4 mg/kg, p.o.) reduced immobility time in the FST, suggesting antidepressant-like properties in mice; F15599 did not disrupt long-term memory consolidation in the NOR at any dose tested, whereas F13714 fumarate impaired memory formation, especially at higher doses (4-16 mg/kg); F13714 fumarate rescued cortical and hippocampal deficits in p-ERK1/2 levels in UCMS mice, but did not affect p-CREB levels.
• In Vitro:
  F13714 targets the 5-HT1A autoreceptor.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5HT Receptor, 5-HT1A, 5HTReceptor, F 14679 fumarate, F 13714 Fumarate

Compound Identifiers

PubChem CID

9958888