F1063-0967

SKU: orb1302965

Description

F1063-0967

Research Area

Metabolism Research

Key Properties

• CAS Number: 613225-56-2
• MW: 484.59
• Purity: 99.15%
• Formula: C₂₄H₂₄N₂O₅S₂
• SMILES: Cc1ccc(\C=C2/SC(=S)N(CCCCCC(=O)Nc3ccc(C(O)=O)c(O)c3)C2=O)cc1
• Target: Phosphatase
• Solubility: DMSO:60 mg/mL (123.82 mM)

Bioactivity

• Target IC50:
  DUSP26:11.62 μM
• In Vitro:
  At concentration above 0.1 μM, F1063-0967 remarkably induces IMR32 cell apoptosis. F1063-0967 induces apoptosis in IMR-32 cell line with an IC50 value of 4.13 μM. F1063-0967 has no effect on HL7702 cell line, and little inhibition effect on SH-SY5Y cell line.
• Cell Research:
  The IMR-32 cells are plated in 96-well plates with 1×103 cells per well. After the cells are allowed to settle for 24 h, F1063-0967 (0, 10, 1, and 0.1 μM) is added. An MTTassay is performed. For cell lines HL7702 and SH-SY5Y, the cells are allowed to settle for 24 h, F1063-0967 (10 μM) is added, then MTT assays are carried out after 72 h.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DUSP26, Inhibitor, F1063 0967, F10630967, F-1063-0967, F1063-0967, inhibit, Phosphatase

Compound Identifiers

PubChem CID

5895168